The standard technique of laryngoscopy and endotracheal intubation involves the stimulation of Larynx, Pharynx, Epipharynx and trachea, which are extensively innervated by Autonomic nervous system, namely the parasympathetic innervation via vagus and glossopharyngeal nerves and sympathetic via superior cervical ganglion. All patients were explained in detail about the study and informed consent was taken. Patients were randomly allocated to receive intravenous Magnesium sulphate infusion 30 mg/kg, 15 minutes before induction of anaesthesia or injection Lignocaine 1.5mg/kg intravenously 90 seconds before intubation. All patients had an peripheral intravenous line secured in the pre-operative holding area. Randomization was done by picking lots. The Anaesthesiologist who prepared and administered the drug was not involved with the intra and post-operative management of the patient. We conclude that Magnesium sulphate and Lignocaine are effective in blunting the hemodynamic response to intubation, but Magnesium sulphate is superior to Lignocaine in blunting the hemodynamic response to laryngoscopy and endotracheal intubation without any significant side effects.