Psoriasis is one of the main dermatological disorders caused by stress. It is important to consider a psychological treatment in parallel to the dermatological treatment Hence we aim to evaluate whether autogenic training is helpful in treating psoriasis as assessed by perceived stress score (PSS),establish a non-invasive panel of biomarkers (salivary versus blood) which may be useful in predicting the disease severity and effectiveness of the therapy in psoriasis. Hundred patients of moderate and severe chronic plaque psoriasis defined as PASI >6 or DLQI >6 , more than 15 years of age will be recruited in this randomized controlled study. Daily autogenic training sessions will be conducted for a week followed by a psycho-education session. Blood samples will be collected to measure the biomarkers using ELISA Technique. Saliva will be collected for the quantification of genetic markers using RT-PCR, miRNA22 BY Real Time PCR-qPCR and whole genome sequencing using Next generation sequencing. Statistical analysis will be carried out using SPSS version 23.