Objectives: Pressure ulcers (PrUs) are the common complications following SCI and there are various options available for PrUs management. In this study the author compared the effect of platelet rich plasma gel dressing of pressure ulcer with normal saline dressing in SCI patients. Design: This randomized comparative study was conducted in PMR department of SMS medical college. Method: Fifty eight SCI patients with PrUs, were randomized into PRP gel treatment group (n=29) and normal saline treatment group (n=29) equally. In PRP group, pressure ulcer dressing was done with autologous PRP gel twice weekly for 5 weeks and in NS group, ulcer dressing was done with 9% normal saline on the daily basis for 5 weeks. Evaluation of PrU healing was done by ulcer staging, measuring wound surface area, Pressure Ulcer Scale for Healing (PUSH), histopathological features of ulcer.