Vacuum Assisted Closure therapy has been shown to be beneficial in a variety of wounds. However, evidence of its benefit in chronic wound in diabetic patients, especially in Indian population is sparse. [1] This Prospective comparative study was carried out between July 2019 to September 2020. The study enrolled 50 patients of chronic wound having diabetes, 25 Patients underwent Vacuum Assisted Dressing in group A while remaining 25 patients underwent Conventional Dressing in group B. Healing duration, Debridement session, Definitive treatment and Total Duration of Hospital stay were compared between group A and group B to conclude which type of dressing method is superior and in the best interest of patients and surgeon. Mean hospital stay was 18.12 days in group A and 36.32 days in group B. Mean debridement session 0.2 in group A and 3.16 in group B. In group A, 22 patients had skin grafting and 3 patients had secondary closure; in group B, 19 patients had skin grafting, 2 patients had secondary closure & 4 patients had amputation, which clearly signifies that Vacuum Assisted Dressing has better outcome as compared to Conventional Dressing. We conclude that, Vacuum Assisted Dressing helps in reducing rate of wound infection, formation of even uniform granulation tissue, requiring less debridement session and less burden of anesthesia associated with other surgical interventions, resulting in early definitive treatment, decreased hospital stay and less consumption of hospital resources.