Introduction: Dengue infection can cause a wide spectrum of clinical outcomes. The severe clinical manifestations occur sufficiently late in the disease course, during day 4–6 of illness. Markers of inflammation may be useful biomarkers. There exists a paucity of research on high sensitivity C-reactive protein (hs-CRP) levels in dengue children. We investigated the value of hs-CRP to predict dengue disease severity in children and the difference in hs-CRP levels between dengue patients and healthy controls.