Introduction: Femoro-popliteal arterial disease is a common vascular condition and Various methods of revascularization have been tried which includes simple balloon angioplasty, debulking techniques , stent implantation , and recently the drug eluting balloons. Paclitaxel drug eluting balloons are more promising in the approach to treat femoro-popliteal arterial disease . Material and Methods: The present study from march 2016 to january 2018 was conducted on 25 cases prospectively in patients admitted to the Department of cardiology sri jayadeva institute of cardiovascular sciences and research center, Bangaluru (Karnataka). femoral artery using cross over sheath VascuQol – 6 disease specific health related quality of life questionnaire post procedure . Results: A success rate of 92% was recorded and patients treated with DCB showed significantly higher primary patency of the affected vessel. The current study reveals that vascuQoL-6 score used to assess the quality of life of the patient with peripheral arterial disease before and after the intervention improved and it is statistically significantly. Conclusion: We conclude that Use of paclitaxel drug coating balloon is safe and efficacious in treating femoro-popliteal arterial disease. Restenosis which was noted in 8% of our cases can be successfully managed with percutaneous transluminal angioplasty using same DCB.