Aim: The aim of this study was to determine the effect of various topical agents in chronic plaque type psoriasis. Material and methods: This was a prospective, randomized study was done in the Department of skin and VD, Vardhman Institute of Medical Sciences, Pawapuri, Nalanda, Bihar, India for one year. Total 100 patients were include and were divided in three groups comprising of 30 patients in each group. Group A patients were asked to apply ammonium lactate twice a day, Group B patients were asked to apply ammonium lactate in morning and clobetasol propionate in evening, Group C patients were asked to apply topical ammonium lactate in morning and calcipotriol in evening. PASI scoring of each patient was done at baseline, at the end of 4 weeks and at the end of 8 weeks. Results: No significant difference was noted between study groups (p=0.649). Further on comparison of individual groups it was found that significant difference was present between PASI at 8 weeks between group A and group B (p=0.039), group A and group C (p=0.027) but between group B and group C (p=0.967) difference was not significant. it was found that 14(46.67%) out of 30 subjects attained PASI 50 in group A, 19(63.33%) out of 30 patients in group B and 19(63.33%) out of 30 patients in group C. Physician global assessment scale shows that in Group A, 7(23.33%) patients had excellent response, 6(20%) patients had good response, and 7(23.33%) patients had fair response whereas 10(33.33%) patients had poor response. In group B, 10(33.33%) patients had excellent response, 11(36.67%) patients had good response, and 4(13.33%) patients had fair response whereas 5(16.67%) patients had poor response. In group C, 10(33.33%) patients had excellent response, 11(36.67%) patients had good response, and 2(6.67%) patients had fair response whereas 6(20%) patients had poor response. Conclusion: We concluded that the combination therapy is effective, well tolerated with minimal side effects and better compliance was seen. Ammonium lactate can also be considered as one of the topical option as a monotherapy and also as a maintenance therapy.