ABSTRACT: BACKGROUND: Pharmacovigilance is the scientific activity of identification, evaluation, understanding, and prevention of adverse drug reactions and other medication-related issues. An “adverse drug reaction” is any hazard, unwanted effect of a drug, which occurs in a normal dose used in humans for prophylaxis, diagnosis, therapy or modification of physiological functions. METHOD: A structured and validated KAP questionnaire was developed and validated clinically, statistically, and also by conducting a pilot study. The reliability was assessed based on Cronbach's alpha score using SPSS version 24. The Cronbach alpha score was found to be 0.773 and it was considered reliable to conduct further study. All the hospital pharmacists who participated in this study were educated about pharmacovigilance using a structured Pharmacovigilance leaflet. RESULT: Among more than 250 Hospital Pharmacist approached for their interest in participating in the study only 150 (60%) pharmacists responded, gave written informed consent and answered the questionnaire. When stated the definition of pharmacovigilance as the detection, assessment, understanding, and prevention of ADR, about 28.7% of respondents strongly agreed with the statement. Nearly 72% of respondents strongly disagree that they have been trained in reporting ADR. Around 53.3% of respondents strongly agree that they did not know how to get the reporting form. CONCLUSION: If trained properly in pharmacovigilance, Hospital pharmacists will improve in knowledge, overcome the barrier, and change their attitude and behavior towards pharmacovigilance and in reporting ADR. The study strongly recommends conducting an awareness program in pharmacovigilance among Hospital pharmacists in India.