Aim: to assess the Clinical profile of patients undergoing spinal Anesthesia with intrathecal bupivacaine with clonidine and intrathecal bupivacaine with fentanyl. Methods: For 1 year, 80 adult patients were enrolled in a prospective double-blind randomised controlled trial at Jawahar Lal Nehru Medical College and Hospital in Bhagalpur, Bihar, India. The patients were split into two classes of 40 patients each at random. Bupivacaine and clonidine (Group “A”). Bupivacaine + fentanyl g (Group “B”) Results: Majority of patients in the both the groups belonged to the group 25 to 45 years. Samples were age matched. The number of males and females in each group was same (n=40) and samples in both groups were matched with respect to sex. Majority of female patients in the both the groups belonged to the group 160 to 170 cms and males 171 to 175 cms, Samples were height matched. Most of the patients 43.25 percent from gynaecology surgery followed by lower limb surgery 31.25 percent and Lower Abdominal Surgery 25 percent. Conclusion: We concluded that the administration of local anaesthetics in combination with opioids intrathecally is an established technique for managing postoperative pain following abdominal, pelvic, thoracic or orthopaedic procedures on lower extremities. Local anaesthetics with opioids demonstrate significant synergy.