Aim and Objectives: The aim of the present study was to assess the safety and efficacy of vaginally administered misoprostol 25mg with intravenous oxytocin for labor induction in term prelabour rupture of membranes. The subjects with rupture of membranes without labor were assigned to receive either vaginally administered misoprostol 25 micrograms or intravenous oxytocin infusion this prospective study was conducted during February 2014 to January 2016 in the Department of Obstetrics and Gynecology of Regional Institute of Medical Sciences, Imphal, India