The study was conducted for the period from April 2016 to March 2017. The study of lactobacilli, which was prescribed by acidophillus Lactobacilli (Probiotics), was included in the treatment of the parasite Cryptosporidium parvam compared to nitazoxanid, based on several criteria including therapeutic efficacy and some blood criteria. The number of egg cyst in the first day of the treatment reached 6640 syst / eggs with a therapeutic efficiency of 22.9%. In the first and second concentrations, the ratio reached 7180, 6460 and 5560 with a therapeutic efficiency of 16.7,25.0 and 35. The number of egg cyst continued to decline to the fifth day. The number of eggs cyst was 40 cysts / eggs and 99.4% The number of red blood cells in total infection compared to control was 5.782 × 109 / L, while there was no significant difference in control. The results showed no significant differences in hemoglobin ratios and the volume of red blood cells between total negative control, total probiotic treatment group, and groups treated with drugs in concentrations II and III, and in the number of white blood cells, granulocyte and monocyte were no differences Between the probiotic group and the negative control group, while all the remaining groups decreased.