Abstract: COVID-19, the global pandemic affecting economic developments has been regarded as severe pulmonary dysfunction disease. The disease has caused significant mortalities all around the world. The reports suggest that major reason for patients’ death are multiple organ failure, sudden cardiac arrest, severe respiratory dysfunction and body shock. These clinical conditions are majorly linked with COVID-19 comorbidities which are severely affecting disease severity. The present study describes pathophysiological findings associated with multiorgan effect of COVID-19. The study describes possible transmission route of the virus, responsible for gastro intestinal problems. The review of pathophysiological findings in COVID-19 provides a perspective to focus our therapeutic research strategies towards controlling the effect of pathogenic virus on indirectly targeted body organs. The present study will help in controlling disease morbidities as well as preventing long term effects of COVID-19.