Background: Amidst the greatest global challenge of COVID-19 to the mankind in recent times, this study was aimed to use a novel COVID-19 Pandemic Mental Health Questionnaire (CoPaQ) to investigate the psychosocial impact of COVID-19 pandemic on general Indian population after the disease has made an impact in the Indian subcontinent. Aim: This study compared the psychosocial impact of the COVID-19 pandemic on the frontline healthcare workers and the general population using CoPaQ. Materials and Methods: A questionnaire-based survey (novel CoPaQ questionnaire) was given as an online “Google form” (in English) to all the participants (N=235). The subjects of both genders, aged > 18yrs, following the inclusion and exclusion criteria, were recruited into Group 1 (n=120; the frontline healthcare workers) and Group 2 (n=115; from the general population), and the responses were compared. Results: The baseline demographic parameters were comparable in both the groups, except that the proportion of younger patients (18-24 years) (40% vs 27.83%, p=0.04) and males (59% vs 41% p=0.005) was significantly higher in Group 1. With respect to the functional parameters related to psychosocial impact, a greater level of anxiety related to risk perception was observed in Group 1 (healthcare workers) (p=0.005). There was no significant difference in terms of obsessive-compulsive behaviour, depression, sleep disorders, general levels of media awareness, and the general sensitivity to surroundings in both the groups. Conclusions: This study helps to identify that the mental health domain most frequently affected by COVID – 19 in healthcare workers is that of anxiety and worriedness related to risk perception, as compared to the general population. The study also helps to contradict the usual belief of anticipating greater psychosocial stress in healthcare workers than the general population. Overall, using the novel CoPaQ, the psychosocial impact of COVID 19 pandemic seems to be comparable in both the groups.