Abstract - A novel, simple, precise, sensitive, rapid and specific high performance thin layer chromatographic method has been developed and validated for the simultaneous estimation of Triamcinolone acetonide, Budesonide, Beclomethasone, Mometasone furoate and Fluticasone propionate in various nasal sprays using common mobile phase. The stationary phase used was precoated silica gel 60F254 plate. The mobile phase used was a mixture of Toluene: Acetonitrile: Triethyl amine [6.5: 3.5: 0.2, v/v/v]. The detection of spots was carried out densitometrically using a UV detector at 240 nm in absorbance mode. This system was found to give compact spots for Triamcinolone acetonide, Budesonide, Beclomethasone, Mometasone furoate and Fluticasone propionate with Rf values of 0.30, 0.46, 0.55, 0.71 and 0.82, respectively. The method was validated in terms of linearity, accuracy, precision, limit of detection, limit of quantification and specificity. The calibration curve was found to be linear between 100-600 ng/spot for all drugs with significantly high value of correlation coefficient [r 2 > 0.99]. The limits of detection and quantitation values reveals sensitive determination of all drugs in various formulations using common mobile phase. The low value of percent relative standard deviation reflects the repeatable and precise nature of the developed method. The average percent recovery for all drugs between 98.00 – 102.0% with low value of percent relative standard deviation indicates the accuracy of the method. The comparison of associated spectra at peak points of start, apex and end of the band or spot for all drugs with very good correlation or peak purity [r > 0.99] indicates specificity of the method. The assay results are found in good agreement with the label claim indicates quantification of all drugs without interferences of sample matrix. The proposed method can be used in the quality control of bulk drugs and pharmaceutical dosage forms with very fast, accurate, precise and specific results