ABSTRACT: Liver is the most important vital organ that carries out metabolism of body e.g. formation of cholesterol and triglycerides, synthesis of glycogen, formation of blood clotting proteins and bile formation. Hepatic damage and subsequent liver failure due to both unintentional and intentional acetaminophen overdose has afflicted patients for decades and includes the metabolic cornerstone pathways that exist within hepatocytes in the microsomes. The side effects of drugs on the hepatocytes have been overlooked for years. Drug induced liver injury is the most adverse effect observed in clinical practices. It accounts for around half of acute liver disorder. Anti tuberculosis drugs and acetaminophen overdose are the main issues that result in death from curable diseases. Metabolism of isoniazid and acetaminophen (APAP) results in the formation of toxic metabolites that results in the oxidative stress and glutathione (GSH) store depletion leads to hepatocellular necrosis and steatosis. Alcohol consumption is also the most common cause of liver cirrhosis. Liver peroxidation is considered to be the major mechanism of alcohol-induced hepatotoxicity. To overcome this oxidative stress, there is need of antioxidants that can balance the redox homeostasis of liver by lowering the APAP overdose effect. Consumption of natural antioxidants derived as secondary metabolites from plants in the form of polyphenols and flavonoids prevent oxidative stress. Medicinal plants are best remedies used for hepatotoxicity caused due to oxidative stress. They are cost friendly, easily available and have no mutagenic effect. Herbal medicines form important part of traditional healthcare system of India.