Background: Tranexamic acid (TXA) is a well-known antifibrinolytic drug that can be taken by mouth, injected into the muscle, or given through a vein. But there isn't much evidence that IV TXA helps reduce the need for blood transfusions during spinal surgery. Method: We used electronic PubMed, Cochrane Central Register of Controlled Trials, and Embase databases to do a meta-analysis of randomized controlled trials (RCTs) and quasirandomized trials (qi-RCTs) that included patients who had different spinal surgeries, such as adolescent scoliosis surgery given with perioperative IV TXA. Two independent researchers looked for more journal articles and conference proceedings by hand.