Background: Recently, homeopathy, the most popular system of therapy, is recognized as one of the components of complementary and alternative medicine (CAM) across the world. It is widely used as palliative and as supportive therapy in cancer patients. Limited studies were reported on patients using homeopathy after surgery, radiotherapy, and chemotherapy, generally for overcoming side effects. Therefore, homeopathic treatment is considered as an add-on to conventional therapy, with almost no interaction with the conventional drugs due to the small dose, and improves lives by providing symptomatic relief, increasing survival time and boosting patient immunity. The present review was conducted to highlight the homeopathic studies conducted on Palliative Care and Comprehensive Therapy in Terminally Ill Cancer Patients.