Background: Over decades the treatment of acute pancreatitis remains debatable with no common consensus on treatment guidelines, with some workers using octreotide infusion and some workers only relying on fluid therapy and symptomatic management. This is the first of its kind double blinded comparative trial between omega 3 fatty acid infusion versus octreotide infusion and its response in cases of acute pancreatitis. Aim: A double blinded comparative trial between omega 3 fatty acid infusion versus octreotide infusion and its response in cases of acute pancreatitis. Material and methods: The was a double blinded randomised control trial study conducted in the Department of General Surgery, Vardhman Mahavir Medical College and safdarjung Hospital, New Delhi, India for one year. Omega 3 fatty acids infusion 60ml/hr over 4-5 hours (250 ml infusion) single dose on admission with 150 ml/hr IV fluid, pain relief with paracetamol/tramadol and H2 receptor antagonist and proton pump inhibitors. (60 patient Injection octreotide 100 mcg IV 8th hourly for 5 days with 150 ml/hr IV fluid (60 evaluation done, on admission and on day 5). Compared on the basis of biochemical values (serum lipase), clinical scoring system in pancreatitis (BISAP score), organ dysfunction score (Marshal scoring). Results: The two groups were comparable in terms of age (omega 3 fatty acid mean age group, 38.6 years and octreotide mean age group 42.2 years). Sex wise 51male patients and 9 female patient in omega 3 fatty acid group and 53 male and 7 female patients in octreotide group. 7 patients in omega 3 fatty acid group had gall stone induced pancreatitis and 7 cases in octreotide group had gall stone induced pancreatitis.44 patients were alcoholic in Omega 3 fatty acid group and 47 patients were alcoholic in octreotide group. The two groups were comparable in terms of demographics, etiology, On admission mean lipase levels in Omega 3 fatty acid group was mean 281.34 and octreotide group was mean 321.11 (p=0.79, not significant) and day 5 lipase levels in omega 3 fatty acid group was mean 108.11 and octreotide group was 151.32 (p=0.05, highly significant). The two groups were comparable in terms of demographics, etiology, On admission mean Amylase levels in Omega 3 fatty acid group was mean 712.12 and octreotide group was mean 651.87 (p=0.66, not significant) and day 5 amylase levels in omega 3 fatty acid group was mean 229.66 and octreotide group was 367.85 (p=0.04, highly significant) . On admission mean BISAP score in omega 3 fatty acid group was 2.17 and octreotide 2.11 (p=0.67, not significant), day 5 mean BISAP score in Omega 3 fatty acid group was 1.19 and octreotide was 1.52 (p=0.0001, highly significant) . Mean Marshal score in omega 3 fatty acid group on admission was 2.71 and octreotide 2.59 (p=0.645, non significant). Day 5 mean Marshal score in omega 3 fatty acid group was 1.11 and octreotide group 2.66 (p=0.0001, highly significant) (Table 7). Mean hospital stay in omega 3 fatty acid group was 3.39 days and octreotide was 5.51days . Conclusion: Omega 3 fatty acid infusion is the future in cases of acute pancreatitis which is cheap and easily available with no side effects and reduces the morbidity and mortality in acute pancreatits with reduced hospital stay in turn resulting in overall reduced medical expenditure. ~~