In this study, we looked at a cross-sectional study of varicella knowledge and attitudes between many students of the medical and nursing domain in a tertiary care hospital in Kannur. Convenient sample selection methods were used to select 265 students for the research. All undergraduate Medical and Nursing students were studying in Kannur Medical College. A selfadministered questionnaire based on English was developed to gather information. The questionnaire comprised 26 questions - 20 questions regarding knowledge, 5 attitude-based questions, and 2 questions regarding practice. SPSS16 was used to analyse the statistical study, entered into Microsoft Office Excel. The objective of the study included evaluating the knowledge, attitude, and immunity status among medical and nursing students and comparing the results between the two students. We found that most of the respondents had good knowledge, attitude, and immunity status regarding varicella with better understanding among medical students than nursing students but showed a lack of interest in taking the vaccine, cost, and fear of getting varicella after taking the vaccine. It is suggested that more knowledge and vaccination programs be held in colleges to teach students and prevent infection. And it also indicates that the institutions can provide vaccines at discount rates to students who are willing to have them. It would be beneficial for our future infrastructures.