ABSTRACT: Background: Schizophrenia is characterized by disordered thoughts, emotions, perceptions, language, sense of self and behavior. Primary caregivers of individuals with Schizophrenia encounter comprehensive care giving challenges that causes physical as well as mental stress and can deteriorate the family functioning. However, if primary caregivers are resilient enough with strong and positive mindset, they can overcome burden associated with patient care and preserve own health and health of family as well. Aim: To assess the relationship between depression, anxiety, stress and resilience perceived by primary caregivers of persons with Schizophrenia Materials and Methods: Primary caregivers of person diagnosed with Schizophrenia disease reporting to OPD and IPD of Department of Psychiatry of Medical College as per DSM-5 diagnostic criteria will be assessed for depression, anxiety, stress and resilience after taking informed consent for the study by applying inclusion and exclusion criteria. Then psychological scales will be applied on these primary caregivers. The Depression Anxiety and Stress (DASS-21) and Brief Resilience Scale (BRS) scales will be applied and accordingly the points will be given. Conclusion: We expect to find significant relationship between depression, anxiety, stress and resilience perceived by caregivers of persons with Schizophrenia.