Background: Schizophrenia is the most incapacitating mental disorder, with a lifetime prevalence of 1% and symptoms often appearing in late adolescence or early adulthood. It is characterised by delusions, hallucinations, disorganised speech, grossly disorganised behaviour or catatonic behaviour, negative symptoms. Antipsychotic (neuroleptic) medications are an essential part of schizophrenia treatment. To keep symptoms under control and prevent relapse, effective care necessitates long-term treatment. Medication adherence can be defined as the extent to which the patient’s medication taking matches that agreed with the prescriber. The current study focusses on medication adherence & various illness related factors. To study relationship between medication adherence & severity of schizophrenia, antipsychotic medication & its adherence, antipsychotic medication & its side effects in patients with schizophrenia. Materials and Methods: It is a cross sectional study conducted in 60 subjects aged 18 – 55 yrs fulfilling the criteria for schizophrenia as per ICD-10 classification. Information collected was intake proforma, Positive and Negative Syndrome Scale (PANSS) scale to assess symptoms severity, Drug Attitude Inventory (DAI-30) to assess positive or negative attitude towards treatment adherence, Udvalg for Kliniske Undersogelser (UKU) side effect scale to assess the side effects of antipsychotics. To assess overall severity of schizophrenia PANSS was compared with CGI scale (clinical global impression scale). A score of (58-74) was considered minimally ill, (75-94) as mildly ill, (95-115) as moderately ill & (=/> 116) as severely ill. The antipsychotics used by the patients in our study are Olanzapine (n=23), Risperidone (n=18), Amisulpride (n=15), clozapine (n=2), Cariprazine (n=1), Trifluoperazine (n=1).