Aim: To study the incidence of dry eye disease (DED) and its association with computer exposure time (CET) among IT professionals. Material/Methods: A cross sectional study was performed on 138 IT professionals who met inclusion criteria. Details regarding type of VDT use and duration of exposure to VDT (hours per day) were noted. A standard computer vision symptom scale (CVSS17) questionnaire was applied to all subjects. DED evaluation was performed which included tear film breakup time (TBUT), Schirmer’s test and ocular surface staining (OSS) with oxford grading scale. Results: Among 138 subjects (54.3% females) average age 28.7±7.8 years. Majority subjects used laptop (n=56, 40.6%), had CET ≥8 hours/day (n=92, 66.7%), Level 3 CVS (n=47, 34.1%) according to CVSS17 score. Cumulative CET showed statistically significant correlation with DED. Ocular surface damage and signs of DED was evaluated. Overall, in our study we found 71(51.4%) showed positive OSS, 89(64.5%) subjects had TBUT ≤10 seconds and 39(28.3%) subjects had Schirmer’s value ≤ 10 mm. Conclusion: We found a higher incidence of DED and CVS among IT professionals with prolonged exposure time to VDT as major risk factor.