Low back (LBP) pain is a common health problem all over the world. Many people suffer from low back pain at some stage of their life. Sixty percent of the Indian population has significant low back pain at some time or the other in their life time. Aims and Objectives: To compare the analgesic efficacy of transforaminal triamcinolone with or without low doses of dexmedetomidine for the treatment of low back pain. Material and Methods: This prospective randomized double blind controlled trial was conducted on Thirty patients (30 in each group) in age group 18-65 years of either sex having low back pain and fulfilling the inclusion and exclusion criteria at MGM Medical college, Navi Mumbai. Institutional ethics committee permission was taken. The study was conducted for a period of 2 years from June 2016 to May 2018. All patients of either sex with age between 18-65 years having incapacitating chronic (several months to several years) low back pain and sciatica unresponsive to non- invasive treatments; suspected arachnoiditis, prolapsed disc, no abnormality, or inconclusive findings were included. . All the patients were assessed at least 1 week prior to the procedure and a standard treatment protocol was advised to them, i.e., combination of oral tramadol 37.5 mg+paracetamol 325mg and gabapentin 300 mg two times a day. All the collected data was entered in Microsoft Excel sheet and then transferred to SPSS software ver. 17 for analysis.