Aim: The aim of this study was to compare the effect of ingestion of clear water and glucose water over 10 hours NPO in elective laparoscopic cholecystetctomy surgery. Material & Methods: An observational study was conducted in Department of Anesthesiology. The study included ASA I-II patients undergoing laparoscopic cholecystectomy surgery. Patients undergoing general anaesthesia were included in the study. A total of 90 patients were included and 30 patients each were randomly assigned to one of the 3 groups. Group A kept NPO after midnight, Group B received 200 ml of clear water, while Group C given 200ml of glucose water 2 hours prior to surgery. Results: There was no significant difference between the groups with regard to weight, age and sex. Patients who had 200 ml of clear water in Group B had lesser variation in serum K+ level and serum lactate level than that of Group A which was statistically significant. Patients who had 200 ml of glucose water in Group C had lesser variation in serum K+ level, serum lactate level, RBS level and no episode of hypoglycaemia noticed as compared to Group A, which was statistically significant. Patients in Group C had lesser variation in serum lactate level, RBS level and no episode of hypoglycaemia recorded as compared to Group B which was statistically significant. Conclusion: We concluded that it is safe to conduct general anaesthesia in patients who have ingested 150 ml of water 2 h prior to surgery. Prolonged withholding of oral fluid does not decrease gastric fluid volume and pH.