Introduction: Injury is defined as a physiological damage of living tissue caused due to physical stress. It can intentionally or unintentionally, caused by blunt and penetrating trauma, burning, toxic exposure or overexertion. This injury can occurs in any parts of the body with different symptoms related with different injuries. Computed tomography (CT) most commonly used diagnostic technique specifically used for organ and tissue damage, whole-body CT is used as a standard diagnostic technique. An autopsy is the final diagnostic examination and considered as a standard diagnostic methods in medicine. The aim of the study was to compare CT scan results, with autopsy results by forensic purposes. Material and method: Present study was retrospective–prospective study carried on 500 injured patients attending OPD of Dr. B.S. Kushwah hospital Kanpur. Patients inform consent was taken. Their age, gender, cause of injury, different area of injury, conciseness, unconciseness, death, complication in conciseness patients was noted. Results: as per the study majority of the patients were mail with the age group of 40 – 60 years. Majority of the patients were conscious having vertigo and bleeding , injured due to transport accident. 84 patients having head injury among them brain death was observed in most of the patients having positive results over CT and autopsy technique. Conclusion: CT scan compared to autopsy is a good method for detecting gunshot injury of head and bone fractures. Were as autopsy is better for detecting minor injuries to organs and soft tissues. Both CT and Autopsy are the best technique for most of the injury cases.