History reveals an understandable reluctance to interfere with the course of labour by hastening its onset partly because the methods were uncertain, bizarre and often dangerous. The penalties of failure and the hazards of delayed labour have been recognised for centuries and have, influenced thinking in obstetrics right upto the present. The present study is a comparative study between oral prostaglandin E2 (PGE2) and intravenous oxytocin (IV oxytocin) for induction of labour carried out at Hospital. One hundred and twenty consecutive patients stated for induction of labour satisfying the selection criteria for the study were alternately recruited to Prostaglandin or oxytocin groups. 7 of 17 patients (77.78%) induced with PGE2 and 8 of 15 (88.89%) patients had spontaneous vaginal delivery. Patient (11.11%) of PGE2 group delivered by outlet forceps. One patient in both PGE2 (11.11%) and oxytocin (11.11%) were delivered by vacfuum extraction.