Hemorrhoids are one of the most common anorectal diseases. Hemorrhoidectomy still stands as the most effective treatment for high grade hemorrhoids and postoperative acute pain as an expected result of hemorrhoidectomy has been experienced by thousands of patients all over the world and hence its only obstacle. Pain control using various invasive and noninvasive methods after hemorrhoidectomy has been constantly under debate and investigation. During the study period, 100 consecutive patients undergoing open hemorrhoidectomy under spinal anesthesia are allotted alternatively to each group. So 50 patients in each group of topical 2% diltiazem and diclofenac suppository. The diltiazem group yielded the lowest visual analog scale (VAS) score on post-operative day zero after surgery (p<0.05). The diclofenac group reported the lowest VAS score on following post-operative day one, two after surgery (p<0.05). There were no complications after treatment with either of these drugs. Topical use of diltiazem gel is appropriate for short-term pain control following hemorrhoidectomy, while diclofenac yields a more sustainable pain control.