Background: To study and compare tacrolimus ointment (0.1%) and clobetasol propionate cream (0.05%) in the management of localised vitiligo. To know the common types of vitiligo, age and sex distribution and to know the percentage of regimentation and adverse effects encountered with tacrolimus ointments (0.1%) and clobetasol propionate cream (0.05%). Material and Methods:The present prospective study includes 50 cases of clinically diagnosed vitiligo attending the outpatient department of DVL, ACSR, Government General Hospital, Nellore from 01/06/2021 to 30/05/2022 over a period of 12 months. In this study patient with focal, local, segmental, lip-tip, mucosal and acrofacial vitiligo were included. Generalized and universal vitiligo (vitiligo vulgaris) were excluded in this study