ABSTRACT Introduction: Glaucoma is not a single disease process, but a group of disorders characterized by a progressive optic neuropathy resulting in a characteristic appearance of the optic disc and a specific pattern of irreversible visual field defect that are associated frequently with raised intraocular pressure. Aims: a) To study the association of primary glaucoma with anxiety and depression in the age group of 40 to 75, b)To study the anxiety and depression in the control group and c) Finally, comparing the results between the two. Materials and Methods: The present study was Cross-sectional observational study. This study was conducted in Department of Ophthalmology, and the Department of Psychiatry, Pavlov Hospital, Calcutta National Medical College and Hospital from Eighteen months. Total 130 patients were included in this study. Result: In my study, mean PHQ Scale Score is significantly higher in the cases [19.3231±5.3564] compared to controls [7.8769±5.1856] (p<0.0001) and the mean GAD 7 Score is also significantly higher in cases [12.1231±4.1098] compared to controls [7.8769±4.9419] (p<0.0001). Association between PHQ scale score and GAD 7 score with type of glaucoma is not significant (p value = 0.983). Conclusion: The duration of anxiety and depression with group was statistically significant (p value 0.004). There are many confounding factors in my study like age, gender, and socioeconomic status but multivariate regression analysis proved that glaucoma is significantly associated with anxiety and depression.