BACKGROUND : With the demand of effective and opioid sparing pain management there is a recent shift from central neuraxial analgesia to myofascial plane block. Recently, External oblique intercostal nerve block is gaining popularity for postoperative pain management as it blocks the anterior branch of intercostal nerve block which is a limitation with serratus anterior plane block. In our study we have evaluated the efficacy of external oblique intercostal nerve block with serratus anterior plane block for postoperative pain management in patients undergoing open cholecystectomy. METHODS AND MATERIALS : 60 patients with ASA 1 and 2 who are posted for open cholecystectomy were selected and randomly assigned into 2 groups. Standard general anesthesia protocol were followed to both the groups Group E – these patients received unilateral EOIN block with 30ml 0.375% ropivacaine along with 8mg dexamethasone. -Group S - these patients received unilateral SAP block with 30ml 0.375% ropivacaine along with 8mg dexamethasone. In these 2 groups of patients the primary parameters observed 1. VAS score at 1st,2nd,4th,6th,8th,12th and 24 hrs 2. time for first rescue analgesia 3. the number of rescue analgesics within 24hrs after surgerywere recorded.