Background:Lichen planus (LP) is a common, chronic inflammatory mucocutaneous disease of unknown etiology and putative autoimmune pathogenesis. The present study compared different treatment modalities of oral lichen planus. Materials & Methods: 78 clinically and histopathological diagnosed cases of oral lichen planus were divided into 2 groups of 39 each. Group I patients were given 0.1% tacrolimus cream and group II patients were given 0.05% topical application of clobetasol propionate. Parameters such as pain on VAS and size of the lesion was recorded at baseline, after 3 weeks and 6 weeks. Results: The mean size (cm2 ) in group I was 5.8, 3.4 and 1.6 and in group II was 4.7, 3.2 and 1.2 at baseline, 3 weeks and 6 weeks respectively. A non- significant difference was observed (P> 0.05). The mean VAS was 2.8, 1.4 and 0.6 in group I and 2.9, 1.8 and 0.8 at baseline, 3 weeks and 6 weeks in group II respectively. The difference was significant (P< 0.05). Conclusion: 0.1% tacrolimus reduced size of the lesion and pain score efficiently than 0.5% clobetasol propionate in patients of oral lichen planus.