Background:Early recognition and prompt initiation of treatment are vital if dengue related morbidity and mortality are to be limited. Dengue when left untreated, the mortality rate is as high as 20%. The case fatality rate in patients with Dengue hemorrhagic fever and Dengue shock syndrome can be as high as 40%. The exact clinical and laboratory profile is crucial for diagnosis as well as successful management of the patients. Objective:To evaluate frequency ofliver involvement and aminotransferase levelchange in dengue fever and to determine relationof transaminase level change with diseaseseverity Methods:A singe centered cross-sectional study was conducted among 60 known cases of dengue. Serum aminotransferase levels were analyzed by Modified IFCC Method (International Federation of clinical chemistry). Results:Majority belonged to 21-30 years (46.7%). Males constituted 68.3%. Most common clinical manifestation was fever (88.3%). Alainine aminotransferase, aspartate aminotransferase were significantly and negatively correlated with platelet count. They were significantly and positively correlated with hematocrit values but platelet count was negatively correlated with the hematocrit which was significant.