Santorpanajanita vyadhi are associated hand in hand with multiple life style induced disorder. Here the same obese lady with having history of Hypertension with Ischemic heart disease got treated with her general physician.She had Oesteo-arthritis at both the knees and had taken pain killer medicines for the relief. So, it was ‘patient-controlled analgesia’ (PCA). Intermittent complaints chest pain and vertigo made her angiography and 2D echo before 3 months of Renal failure. Her sedentary life style hetu continue with time and her bad knees doesn’t allow to even walk. Which ultimately lands in time towards cardiac disorder, which made her shift to statin drugs with antiplatelets drugs and anti-hypertensive management. Within one and half month’s patient have symptoms of Nausea, vomiting, Anorexia, Dysuria with Giddiness & higher values in Blood urea level with Serum Creatinine.