Aim: The aim of the study to analyse the thyroid profile, hs-CRP and lipid profile in newly detected hypothyroid adults. Material and methods: The study was a cross sectional study which was carried in the Department of Cardiology, Indira Gandhi Institute of Medical Science, Patna, Bihar, India for 1 year. Total 220 patients were divided into 2 groups. Group-1 for newly detected hypothyroid adults and Group 2 as Controls. Blood samples were collected with full aseptic precautions after obtaining informed consent. Clot activator that contains vacuum evacuated tubes for analysis of serum TSH, FT3, FT4, TC, HDL-c, LDL-c, TG, hs-CRP. Then after collection, serum samples were stored at -200 until analyzed. Anthropometric measurements for BMI, height (cm) and body weight (kg) were measured. Results: The mean age of cases and controls in our study was found to be 37.22±13.21years and 36.97±12.06 years respectively (p = 0.79). Approximately 86.36% of cases and 72.73% of controls were females depicting a female preponderance. BMI values in the study were higher in cases (27.79± 4.77kg/m2) compared to controls (25.67± 4.46kg/m2) and was statistically significant (P = 0.03). In the study, the mean TSH levels (15.77 ± 9.9µIU/ml) of cases were high compared to controls (3.7 ± 0.98µIU/ml) and was statistically significant (p < 0.001). The mean serum hs -CRP levels in both the study groups was within the reference range, but it was high and statistically significant in cases than in control (p = 0.003). The total cholesterol level in cases (183.39 ± 40.75mg/dl) and control (185.37±29.37mg/dl) were within the reference range and there was no statistical significance (p = 0.78). Further it was found that HDL-c in cases (49.39±9.37mg/dl) and control (53.57±6.6mg/dl) were found to be lower in cases compared to controls and the difference was statistically significant (p < 0.001). The mean LDL c value in cases (146.14±34.12mg/dl) and control (133.05±32.14mg/dl) was high in cases and the difference was statistically significant (p=0.01). The triglyceride levels of cases (157.26±49.87mg/dl) were significantly higher than that of control (144.23±29.27mg/dl) and was statistically significant (p=0.02). hs -CRP levels were in within reference range for 85 (77.27%)of cases and 103(90.64%)controls whereas above the normal range was seen in 25 (22.72%) cases and only 7(6.36%) controls. Conclusion: The hypertriglyceridemia and at risk hs-CRP levels though seen in hypothyroid cases were more prominent in CH cases than SCH.