European Journal of Molecular & Clinical Medicine

Cleaning and shaping of the root canal space is the primary objective of endodontic therapy. Its purpose is to prepare the canal space in order to improve disinfection with the use of irrigants as part of chemo mechanical preparation. Infiltration and subsequent infection of the root canal system by microorganisms and their byproducts is the primary etiology of endodontic pathosis. Chemo-mechanical preparation aims to remove microorganisms, remaining pulp tissue and dentin debris from the root canal system.
The main objective of shaping is to maintain or develop a continuously tapering funnel from the canal orifice to the apex; however the complex canal anatomy causes instrumentation challenges, which may prevent adequate disinfection of the root canal system, or cause procedural errors such as instrument separation, transportation, ledges or perforations. The present study was set out to determine canal centering ability, transportation and curvature using 5^th generation NiTi rotary systems as mentioned above.

Diseases of the gastrointestinal tract are often accompanied by changes in
the oral cavity. This is largely due to morphological and functional unity of the mucous
membrane of the mouth and entire digestive tract. According to numerous publications in
recent years, at the end of the XX-beginning of the XXI century, there is a significant
increase in the number of people suffering from cancer of the colon and rectum. This
localization accounts for 15% of all initially diagnosed tumors of all localizations (30% of
them are represented by rectal cancer).

Recently, there has been a significant increase in the number of cancer diseases worldwide. Mortality from malignant tumors is second only to pathologies of the cardiovascular system. Oncological diseases take many lives not only among the elderly, but also among the relatively young generation.