European Journal of Molecular & Clinical Medicine

Alopecia is a common dermatological complaint. Affected people are frequently upset and attempt to stop hair loss by taking a variety of over-the-counter vitamin and mineral supplements. However, the evidence for their effectiveness is limited. Nutrients are thought to play a major role in non-scaring alopecia. We reviewed the literature about the most common micronutrients, vitamin D and iron as well as their significance in the hair follicle cycle and hair loss treatment.  2 independent researchers reviewed peer reviewed papers published in the English language. In the present study, we sought to evaluate the possible roles of vitamin D and iron in non-scarring alopecia.   A thorough literature search of the PubMed, Google Scholar and Research Gate databases was conducted to assemble published studies on the association between alopecia, blood vitamin D, iron, and ferritin levels. In this review we have found that a substantial link between vitamin D, iron and non-scarring alopecia. However, vitamin D and iron administration in correcting hair loss and managing these conditions are lacking. Hence, further studies are needed with larger number of subjects to know the role of these nutrients before vitamin D and iron can be routinely recommended as a treatment modality in these conditions

Background: Iron deficiency has been related toimpaired cardiac function and altered myocardial structure in animal models. The present study was conducted to assess ferritin deficiency in heart failure cases.
Materials & Methods: 58 patients of heart failure of both genders were included and parameters such as ferritin, serum iron, total iron binding capacity, transferrin and transferrin saturation(TSAT) were measured.
Results: 58 patients were taken in which males were 38 and females were 20. Iron deficiency was seen in 12 males and 18 females and no iron deficiency was observed in 15 males and 13 females. The difference was non- significant (P>0.05). The mean hemoglobin in iron deficiency patients was 11.2 g/dl and those without iron deficiency was 13.6 g/dl. Iron level was 56.8 µg/L and 92.5 µg/L, MCV was 84.2 fl and 90.6 fl, TSAT was 14.1% and 29.7% and ferritin was 78.4 µg/L and 265.2 µg/L respectively.
Conclusion: Anaemia is a very common comorbid condition in patients of heart failure. Serum ferritin was significantly reduced in iron deficiency patients.

Background: Many newer tests are now available to diagnose iron deficiency in CKD but these tests are not widely used in India as these tests are expensive and patients cannot afford these tests. Hence the traditional tests serum ferritin and transferrin saturation are needed to be studied more thoroughly to infuse IV iron to patients with iron deficiency anemia in CKD as many cannot afford ESAs and blood. Ferritin is an important indicator of iron overload as well as an acute phase reactant which increases in inflammatory conditions. Serum ferritin getting raised both in iron deficiency anemia and inflammatory states complicates our diagnosis. In this scenario TSAT plays important role in ruling out iron overload and inflammation is ruled out by inflammatory markers.
Objective: To study the effect of IV iron in patients with serum ferritin >1000ng/ml and TSAT <20%.
Methodology: This study was conducted at Department of Medicine, M.L.B. Medical College; Jhansi from March 2020 to November 2021, after seeking clearance from ethical committee and obtaining written informed consent from patient.
Result: It was seen than 18 patients showed improvement and had increase in Hb by 1g/dl. 1 patient had a reaction and transfusion was stopped immediately and 1 patient was lost to follow up.
Conclusion: Against the popular belief that infusion of iron in patients with raised serum ferritin should not be given, this study showed that after ruling out other causes of raised serum ferritin and iron overload by calculating TSAT, IV iron can be given to patients with raised serum ferritin as it shows improvement in anemia.

Background: Anemia is a common complication in Chronic kidney disease (CKD) patients. It has a multi-factorial pathogenesis. Replenishing iron stores and giving ESAs are the main lines of treatment. There is a general agreement on the optimal route for iron supplementation in ESRD patients with the IV route but there is no such agreement on the optimal route for iron supplementation in pre-dialysis CKD patients. Erythropoiesis stimulating agents (ESAs) treatment represent an economic burden and has been linked to possible cardiovascular side effects. This study amid to assessing the efficacy of erythropoietin in treatment of anemia in CKD patients. Methods: A prospective cohort study was conducted in chronic kidney disease patients who had undergone hemodialysis in Met-Ghamr hospital of nephrology from February 2019 to July 2019. Included 50 patients on maintenance hemodialysis, we tested the efficacy through comparing the efficacy low fixed ESA dose (4000 IU IV once weekly) versus high fixed dose (4000 IU IV three times weekly). We divided group into two groups, group A and group B. group A were put on a fixed dose of 4000 IU Epoetin alfa once weekly and group B were put on a fixed dose of 4000 IU Epoetin alfa three times weekly. Results: After 6 months, We found a significant difference in hemoglobin response of the two subgroups in favor of subgroup IID (P = 0.004). Conclusion: That low dose ESAs is less effective in correction of anemia in dialysis patients than high dose ESAs.

Abstract. The results of the effect of complex treatment on periodontal
microcirculation in patients with chronic periodontitis occurring with an iron deficiency
state.
Purpose of the study: to study periodontal microcirculation in patients with chronic
periodontitis occurring against the background of iron deficiency states.
Materials and methods: As the research sources, 100 patients who applied to the
Samarkand regional dental clinic suffering from chronic periodontitis and iron deficiency
were selected. The patients were divided into 2 groups, of which 1 main group consisted of
50 patients who received glycodent gel and an iron preparation (combined iron (II) sulfate
- sorbifer durules / ascorbic acid). The second group received the generally accepted
standard therapy for chronic periodontitis. The diagnosis of iron deficiency states was
established by determining the parameters of iron and ferritin in the blood.
Microcirculation was studied using the "Lazma" apparatus (Russia).
Results and discussion: A positive effect on microcirculation of the complex of
treatment with glycodent gel and an antianemic drug for chronic periodontitis with an iron
deficiency state was revealed.

A field trail was conducted to evaluate the efficacy of foliar application of iron on nutrient availability in wheat grain. The plot design was RCBD with three replications and eight treatments. T1: Control (without fertilizer), T2: Control (with RDF), T3: RDF+ FeSO4 + Urea (at flowering stage), T4: RDF + FeSO4 (at flowering stage), T5: RDF + FeSO4 + Urea (at milking stage), T6: RDF+ FeSO4 (at milking stage), T7: RDF+ FeSO4 + Urea (at pre-maturity), T8: RDF + FeSO4 (at pre-maturity). After harvesting, estimation of nutrients in grain revealed that for most of the nutrients application of Fe at flowering and miliking stage has great impact on increased nutrients in grain.

The experiment was conducted in Agriculture filed of Lovely Professional University, Jalandhar with wheat variety viz. HD 3086 to know the effect of foliar application of iron on nitrogen uptake and its combined impact on growth and yield of wheat. The plot design was RCBD with three replications and eight treatments. T1: Control (without fertilizer), T2: Control (with RDF), T3: RDF+ FeSO4 + Urea (at flowering stage), T4: RDF + FeSO4 (at flowering stage), T5: RDF + FeSO4 + Urea (at milking stage), T6: RDF+ FeSO4 (at milking stage), T7: RDF+ FeSO4 + Urea (at pre-maturity), T8: RDF + FeSO4 (at pre-maturity). The observed parameters plant height, length of spike, number of tiller, effective number of tillers, test weight of grain, number of spike lets per spike, number of grain per spike were taken at regular interval of 60, 90 ,120 DAS. In case of yield parameter the maximum test weight was recorded in T3 (49.75) and minimum was in T3 (45.09). For harvest index maximum value was recorded in T3 (45.42) and minimum in T1 (43.49). According to result, better growth and yield parameter was observed in treatments T3 due to foliar spray of iron and urea. Iron acts as catalyst and regulate many enzymatic activities which helps in better growth and increase in the yield, whereas urea is a source of nitrogen and in plants growth nitrogen play very important role because it helps in the synthesis of chlorophyll and many other activities.

Objective: The aim of this systematic review is to review studies on the effect of dates on increasing hemoglobin levels in anemia
Methods: the method used is an electronic database that has been published through the online libraries PubMed and Sciendirect. The keywords used for article searches are based on research questions. Result: a review of six health articles stated that dates are effective for increasing hemoglobin levels. Dosage, timing of administration, type of dates, food intake, a person's health condition should be of particular concern in giving date palm interventions. Not only increase hemoglobin levels, dates can also play a role in increasing ferritin, hematocrit, transferring saturation and serum iron levels in the majority of people.
Conclusion: dates can be used as an additional alternative to increase hemoglobin levels. However, disease or systemic syndrome in each person should be a concern because it can affect the effectiveness of dates in increasing hemoglobin levels.