European Journal of Molecular & Clinical Medicine

WHO has reported that, 2.3 million women were diagnosed with breast cancer in 2021 and 685000 deaths occur globally due to breast cancer. As estimated at the end of 2020, there were 7.8 million women diagnosed with breast cancer in the past 5 years were alive, making it the world’s most prevalent cancer. Breast cancer is the most common cancer type in Indian female, and many patients suffer from recurrences and metastasis. There is no marker to predict the severity and invasiveness of breast cancer. Single-stranded, non-coding RNA molecules called microRNAs (miRNAs) control the expression of target genes through post-transcriptional alterations . Numerous studies suggested that miRNA has a promising role in the diagnosis and prognosis of various malignancies. In a number of malignancies, including gastric cancer, esophageal squamous cell carcinoma, breast cancer, and prostatic cancer, miR-22 is aberrantly expressed either up or down. miRNA-22 may be used a diagnostic as well as prognostic marker for breast cancer.
 

Understanding the etiology and pathogenesis of periodontal diseases and their chronic, inflammatory and infectious nature necessitates recognizing the possibility that these infections may have effects somewhere in the body. The concept that oral diseases and systemic diseases influence each other goes back to the theory of “focal infection”. In 1891, Miller published his theory regarding focal infection in which he indicated that microorganisms and their products are able to access parts of the body that are adjacent to or distant from the mouth. The proponents of this concept assume that microorganisms present in dental plaque and their metabolic products may enter the bloodstream, thereby causing many systemic diseases and sometimes resulting in degenerative conditions. Associations have been reported between periodontal disease and cardiovascular disease (CVD), stroke, diabetes, preterm low birth-weight babies, respiratory infections and rheumatoid arthritis (RA).

Obesity is disorder in a foremost nutritional health it’s developed with countries developing. Also is known as increasingin fat accumulation that lead toproblem in health, besidesmay coin one of the reasons lead toloss of life,the obesity not effect on adults just but effect onoffspringand juveniles. In some ofinhabitants the incidence of obesity is superior in female than in male; on the other hand, the variation degree of the between the genderdifferby country.Obesity is generally measured by body mass index and waist circumference, Obesity are classified according to body mass index into:Pre obesity sort 1 : (25 - 29.9) kg/m2, Obesity sort 2 : (30 - 34.9 kg/m2) and extreme obesity sort 3: (40 kg/m2) or greater. Obesity is described by a pathologic condition with augmented overall of cholesterol, triglycerides, LDL cholesterol while reduced of HDL levels.There are many hormones causes pathophysiology of fatness such as adipokines, gutcorrelated hormones and ghrelin, numerous studies have revealed that the association among fatness and the metabolic sickness such as Insulin resistance, activity of lipoprotein lipase in muscle reduction and free fatty acids increasing. Conclusion: Obesity and overweight different between men am women according to quality of life in different population and countries

Statistically significant association of allele G and hetero A/G,
homozygous genotype G/G polymorphism rs1801394 MTRR gene with risk of autism
development was revealed. The presence of allele A and genotype A/A polymorphism of the
rs1801394 MTRR gene reduces the risk of autism. Identification of allele G increased the
risk of autism by 1.4 times compared to the presence of allele A (95% CI = 0.68-2.93, df=1).
The presence of the allele G of MTR A2756G polymorphism correlates with an increased
risk of autism.

Cholera is a contagious diarrheal disease which spreads through contaminated food and water. It is caused by Gram negative bacterium Vibrio cholerae of the O1 or O139 serogroup. Cholera can potentially spread as epidemic or endemic. If undiagnosed and untreated at the earlier stages, it can result in dehydration and death. Different endeavors are made for the treatment of cholera. Oral rehydration therapy (ORT), use of antimicrobials and antibiotics, probiotics and vaccinations are amongst the various alternative modes of treatment that can be used to treat cholera depending upon the severity of the disease. Also, antibiotics like tetracycline, azithromycin and doxycycline can be used synergistically for the treatment of acute infection and intense dehydration. Researchers have also advocated the use of different vaccines including oral cholera vaccine. In this review, we have provided a brief overview of the cholera disease and its pathogenesis along with different treatment strategies that can be used to treat it or reduce its symptoms.

This article discusses modern approaches to treating vitiligo and lists the methods of treating vitiligo.It was used to treat vitiligo in 28 patients. Most of them enjoyed of clinical condition. The preparation was well tolerated and produced no adverse effects.

The results of the study of the distribution frequency of the genotypes of the
polymorphism of the rs1800629 TNF-α gene involved in the formation and clinical course
of rosacea are revealed, which allows us to predict the development, course of the disease
and to develop the optimal scheme for its prevention and treatment. We studied the
polymorphism of the rs1800629 TNF-α gene in rosacea patients and determined the
effectiveness of therapy depending on the severity and frequency distribution of genotypes