European Journal of Molecular & Clinical Medicine

Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. In patients with Type 2 diabetes, low grade inflammation is reflected by increased plasma levels of several biomarkers  such as C-reactive protein (CRP).Alkaline phosphatase (ALP) is a generally accepted clinical marker of hepatic or bone disease.It had been showed that elevated ALP acted as a prognostic indicator of decreased survival in diabetic patients with acute myocardial infarction (MI), possibly in association with decreased renal function in these patients

Objective: The current study aimed to compare the levels of zinc, alkaline phosphatase, and random blood sugar in people with leprosy to those in healthy controls from the Bundelkhand area. The second objective was to compare the correlation between study parameters in the leprosy group and the healthy control group. Material & methods:  The research was carried out in the Department of Biochemistry at Maharani Laxmi Bai Medical College (MLBMC) in Jhansi. In the healthy control group, forty human beings with normal glycemic status were age and gender matched. The leprosy patient group contained forty leprosy patients who were receiving treatment. Leprosy disease was diagnosed in accordance with the world health organization guidelines. Results: Age difference between the two groups was not statistically significant in the present investigation. Whereas, we found a statistically significant contrast between the two sets of data we analyzed, including RBS, ALP, and serum zinc levels. Leprosy patients showed a positive link between ALP and zinc, and a negative correlation between age and RBS; RBS and serum zinc. A positive connection between ALP and zinc was seen in the control group. We conclude that periodic monitoring of zinc concentrations in leprosy people may be prudent since zinc deficiency worsens insulin resistance and may lead to greater loss through urine.