European Journal of Molecular & Clinical Medicine

Background: The evaluation of thyroid function in systemic illness remains complex because the changes occur at all levels of the hypothalamic-pituitary-thyroid axis. So, it is prudent for the internist and treating physician to be aware of thyroid dysfunction so that early intervention can be instituted to improve the outcome. The aim of this study to correlate the severity of chronic renal failure and alteration of thyroid indices at tertiary care centre.
Materials& Methods: A hospital based prospective study done on 40 chronic renal failure patients admitted in medical ward at KPC Medical College, Jadavpur, Kolkata, West Bangal, India during one year period. Patients who fulfill the criteria for CRF and who are on conservative management were taken for the study. The correlation between the thyroid indices were analyzed and interpreted by the Karl Pearson’s coefficient(r). The interpretation of statistical procedures was performed by the statistical package SPSS (22.0 V). The value of P<0.05 was considered as significant.
Results: Among 40 patients, 10 patients were female, and 30patients were male. The mean age of the male and female patients was 52.76±11.65 and 50.45±7.32 years respectively. The prevalence of low T3 syndrome was 52.5% (21 cases) and the low T4 syndrome was 22.5 % (9 cases). The prevalence of TSH in hypothyroidism range was 5% (2cases). Among the males 46.66% of patients had low T3 syndrome. And among the females was 70%. The difference was not statistically significant P>0.05. The prevalence of low T4 among the males was 20% and among the females was 30%. The difference among the sexes was not statistically significant i.e. P>0.05. Theprevalence of TSH in clinical hypothyroidism range among males was 3.33% and among the females was 10%. The prevalence between the sexes was not statistically significant(P>0.05).
Conclusion: We concluded that serum level of total T3 and free T4 is directly proportional to creatinine clearance level. Alteration in the values of T3 and T4 occurs as a part of body adaptation mechanism to conserve energy.