Online ISSN: 2515-8260

Keywords : Bisphosphonates

“A Dual and Correlate bone Mineral Density and Periodontitis Among Post-Menopausal Women”

Dr. Girish Suragimath Prof, Dr. Nikhil Awale, Dr. Vaishali Mashalkar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 4851-4880

Both periodontitis and osteoporosis represent major health problems, with increased incidence and severity with advancing age, all over the world. Osteoporosis, though not being the initial cause of periodontitis, has been shown to be risk indicator that may contribute to the progression of periodontal disease. Some interventions that improve systemic BMD also improve measures of periodontal disease. Improvement of the two conditions by the same therapies suggests an underlying connection.
The three classes of therapy that have been implicated in this regard are
1)          Hormone replacement therapy (HRT)
2)          Diet supplementation with calcium and vitamin D
3)          Bisphosphonates
A bone mineral density (BMD) test is used to measure an individual’s bone mass. BMD is measured using a DEXA scan. Most common cause is involutional bone loss in postmenopausal age group. Osteoporosis may be a primary disorder or secondary to other diseases or conditions. Primary osteoporosis includes idiopathic and involutional form. Idiopathic forms of osteoporosis are rare and affect men and women equally. Involutional osteoporosis includes two patterns type I (postmenopausal) and type II (age related) osteoporosis.
The present study was designed to assess and correlate bone mineral density and periodontitis among post-menopausal women

Surgical outcome assessment in femoral fracture patients with or without teriparatide treatment


European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 1445-1450

Introduction: Femoral fracture and atypical subtrochanteric fracture are thought to be uncommon side effects of long-term bisphosphonate treatment. Delay in bone healing may be caused by a decreased rate of bone turnover. Limited research has shown that teriparatide therapy may counteract the effects of bisphosphonates and promote bone repair.
Methods: A retrospective assessment of individuals with atypical subtrochanteric and femoral fractures associated with the use of bisphosphonates were examined. There were 18 female patients signed up. The characteristics of an unusual fracture were congruent with the radiographic findings. All underwent surgical intervention, and teriparatide usage was suggested after surgery. Perioperative results, clinical, and radiographic outcomes were all considered outcome indicators.

Retrospective evaluation of atypical periprosthetic femoral fractures and its associated risk factors


European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 1451-1458

Aim: To evaluate atypical periprosthetic femoral fractures, its outcomes and its associated risk factors.
Methodology: This is a retrospective observational study carried out during duration of 2 years (April 2020 - March, 2022 at the Traumatology Department of college. All consecutive adult patients admitted with subtrochanteric or shaft fractures were evaluated with respect to the following inclusion and exclusion criteria. Inclusion criteria are based on the clinical and radiological features of AFF as defined by the American Society for Bone and Mineral Research major criteria. During the study period, 90 patients with subtrochanteric or femoral shaft fractures treated in the hospital that met the inclusion criteria. Of these, 10 patients had bilateral fractures on presentation. Surgeries were performed by trauma surgeons, and patients underwent standard rehabilitation following the procedure. Demographic information and surgical details were recorded from the hospital electronic records. The quality of reduction was evaluated by the postoperative standard X-rays in the anteroposterior (AP) and lateral views using digital pictures.