Keywords : Restrictive pattern
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 2413-2418
Background:Body adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. This study aimed to investigate whether thyroid function is associated with various regional fat quantities in euthyroid subjects.
Materials and Methods: This is a cross sectional study conducted on 90 patients divided into 2 groups (a) newly detected hypothyroids (b) normal control group. Cases were matched with controls in having similar environment exposure and age group. All patients had routine symptom and clinical assessment. Laboratory investigations such as complete blood picture, pulmonary function test, chest x ray and thyroid function test were done. Data was entered and analyzed.
Results: In this study author observed a significant decrease in FEV1 and FEV1/FVC ratio in hypothyroids. FVC between cases and controls did not show statistical significance, although the mean FVC was found to be lower in cases (1.44) as compared to controls (1.79). The various respiratory patterns seen in cases were as follows: obstructive pattern (32%), followed by mixed pattern and restrictive pattern (28%, 22% respectively). Furthermore, we observed that there was no significant correlation between TSH or fT4 with FVC, FEV1, and FEV1/FVC.
Conclusion: This study shows that hypothyroidism causes significant decrease in FEV1 and FEV1/FVC ratio, thereby suggesting obstructive patterns of lung involvement. Therefore, PFT can be used routinely as a screening test for all hypothyroid patients to detect early respiratory dysfunction and thereby optimize treatment especially in obese patients and patients with pre-existing lung disease as hypothyroidism adds to their respiratory dysfunction.