Online ISSN: 2515-8260

Keywords : Anti-GAD antibody

Immunological profile of youth onset Diabetes Mellitus patients

Sanjay Nath Jha, Gopi Nath Dubey, Sushil Kumar, Vinya Nand Jha

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 677-683

Background & objectives: There has been a rise in the occurrence of diabetes mellitus
in the youth population of India. There is restricted information accessible on the
immunological profile of youth beginning diabetes mellitus (DM) particularly in type 2.
Hence, this study was embraced to assess the clinical and immunological profile of
youth beginning DM in east India.
Methods: Fifty-one successive patients of 7–36-year-old enough with diabetes mellitus
going to the Darbhanga Medical College Hospital, Laheriasarai were remembered for
the review. All subjects were tried for glutamic acid decarboxylase (GAD), an islet cell
antigen ICA512/IA2, and insulin antibodies. Stray and ICA512/IA2 were finished by
ELISA and insulin autoantibodies were tried by radioimmunoassay (RIA) technique.
These patients were likewise evaluated for hepatitis A to E, cytomegalovirus (CMV) and
Epstein-Barr Virus (EBV) as trigger elements for the beginning of type 1 DM.
Results: Of the total 51 patients, 38 were male and 13 were female. The mean age and
BMI of the subjects were 19.7 (±7) years and 21 (± 5) kg/m2, separately. Twenty
patients were beneath the age of 18 years and their stature was more than 75th
percentile of Indian norms. All patients were indicative and 12 of these gave
ketoacidosis. Just 48% (n=24) were positive for GAD, 14% (n=7) for ICA512/IA-2, and
28% (n=14) were positive for insulin neutralizer. Five of these patients had proof of
hepatitis E virus infection. None of the subjects had proof of dynamic CMV or EBV