Online ISSN: 2515-8260

Keywords : ferritin

A Case control study on the Association of Serum Ferritin levels with Acute Myocardial Infarction

Vadiga Ramana Kumar, Atul Pundlik Ramteke, Guguloth Prem Kumar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 2647-2655

Background: To evaluate the serum ferritin levels in patients with acute myocardial infarction. To inspect normal healthy individuals with non-cardiac chest pain for serum ferritin levels. To distinguish ferritin levels persisting in both the study population. Comparing serum ferritin levels to the probability of developing acute myocardial infarction. To study relevance of serum ferritin level to acute myocardial infarction.
Material and Methods: A case controlled study was held by Department of General Medicine, Government General Hospital, Suryapet, Telangana, India from December 2021 to September 2022. The study consisted of male patients with myocardial infarction for determining the association of serum ferritin to acute myocardial infarction.
Results: The statistical analysis data for the evaluation of study details for different diagnostic test between cases and control group and determines significance between them. Comorbidities associated with cases and control shows that evidence of diabetes mellitus. The comparison of ferritin and lipid profile no significance existed. On differentiating ferritin administrated value to that of day 3 shows statistical significance. While comparing ferritin and glycaemic control, correlation prevailed. A mixed results were obtained from performed study that proved insufficient to correlated ferritin with myocardial infarction.
Conclusion: The study contradicted the hypothesis. Neither of the tested iron biomarkers confirmed the iron hypothesis, based on the meta-analysis. These finding suggest that the evidence is not robust enough to support the connection among iron and cardiovascular disease. This discrepancy in results could be due to the study's use of different iron markers. Despite the large amount of data that has been published to far, the importance of iron in CVD is still up for debate.

In Type 2 Diabetes, A Study Examined the Correlation Between Serum Ferritin and Hba1c

Sajjad Ahsan, Nazish Raza, Zamin Ahsan, P K Aggrawal

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 1397-1401

Background: Diabetes mellitus type 2 (DMT2) is one of the most prevalent endocrine
illnesses, affecting about 135 million individuals globally. The disease's genesis is
unknown, but subclinical hemochromatosis has recently been identified as one of the
possible causes of DM. The purpose of this study was to look at the association between
serum ferritin as a measure of iron excess and diabetes and HbA1c.
Methods: This 12-month study was carried out in the Medicine department of Katihar
Medical College Hospital in Bihar, India. 46 patients with T2DM were used as cases in
this case control study. The control group consisted of 46 healthy individuals who were
age, gender, BMI, and haemoglobin percent matched to the case group. Blood samples
were tested for ferritin, haemoglobin, HbA1c, and fasting plasma sugar. Anaemia and
any other ailment or medicine that could alter ferritin levels were exclusion criteria.
Result: The Pearson correlation coefficient test, Student's t-test, Chi-square test, and
Odds ratio were used to assess the results statistically. Diabetics had considerably
higher mean serum ferritin levels than the control group (197.97± 75.99 gm/L vs. 64.24±
27.83 gm/L, p<0.001). In diabetic patients, there was a substantial positive connection
between HbA1c and serum ferritin (p<0.001). In this investigation, an OR of 11.64 was
also discovered.
Conclusion: Serum ferritin levels are associated with T2DM patients. This could be a
significant and independent predictor of the development of diabetes mellitus

Use of IV iron in iron deficiency anemia in CKD with raised serum ferritin

Dr. NS Sengar, Dr. Rambabu Singh, Dr. Preeti Gupta, Dr. Patel Jivabhai Girish Kumar, Dr. Hardeep Jogi, Dr. Nitin Gupta .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1274-1279

Background: Many newer tests are now available to diagnose iron deficiency in CKD but these tests are not widely used in India as these tests are expensive and patients cannot afford these tests. Hence the traditional tests serum ferritin and transferrin saturation are needed to be studied more thoroughly to infuse IV iron to patients with iron deficiency anemia in CKD as many cannot afford ESAs and blood. Ferritin is an important indicator of iron overload as well as an acute phase reactant which increases in inflammatory conditions. Serum ferritin getting raised both in iron deficiency anemia and inflammatory states complicates our diagnosis. In this scenario TSAT plays important role in ruling out iron overload and inflammation is ruled out by inflammatory markers.
Objective: To study the effect of IV iron in patients with serum ferritin >1000ng/ml and TSAT <20%.
Methodology: This study was conducted at Department of Medicine, M.L.B. Medical College; Jhansi from March 2020 to November 2021, after seeking clearance from ethical committee and obtaining written informed consent from patient.
Result: It was seen than 18 patients showed improvement and had increase in Hb by 1g/dl. 1 patient had a reaction and transfusion was stopped immediately and 1 patient was lost to follow up.
Conclusion: Against the popular belief that infusion of iron in patients with raised serum ferritin should not be given, this study showed that after ruling out other causes of raised serum ferritin and iron overload by calculating TSAT, IV iron can be given to patients with raised serum ferritin as it shows improvement in anemia.

Assessment of iron overload in beta thalassemia major patients by serum ferritin level

Dr. Palak Yogeshbhai Thakkar, Dr. Neelaba K Mori, Dr. Chandrika G Algotar, Dr. Tejas S Chokshi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 828-832

Context: Beta Thalassemia major is a genetic disease with an autosomal recessive pattern of
inheritance that occurs as a result of disorder in haemoglobin synthesis. In Beta Thalassaemia
major patients multiple blood transfusions, ineffective erythropoiesis and increased
gastrointestinal iron absorption lead to iron overload in the body. Iron overload can be
determined by Serum Ferritin measurement.
Aim and Objectives
1. To Assess the average frequency of blood transfusion in Beta Thalassemia Major patients
2. To measure Serum Ferritin level in Beta thalassemia Major patients
3. To determine the association between Serum ferritin level and age, average frequency of
blood transfusion in Beta Thalassemia Major Patients.
Methods and Material: Fifty blood samples of clinically diagnosed Beta Thalassemia major
patients were collected for estimation of Serum Ferritin levels. Serum Ferritin measurement
was performed using indirect enzyme linked immune sorbent based assay kit. Data were
analysed to determine association between Serum Ferritin and age, gender and frequency of
blood transfusion.
Statistical analysis used: Descriptive statistics, Regression, Correlation
Results: The mean Serum Ferritin level was found to be 3639.75 mg/ml. Five patients had
Serum Ferritin <1000 mg/ml, Twenty three patients had Serum Ferritin between 1000-3500
mg/ml and twenty two patients had Serum Ferritin >3500 mg/ml.
Conclusion: The study showed high levels of Serum Ferritin in Beta Thalassemia major
patients. Serum Ferritin levels should be monitored regularly to assess the status of iron
overload and to rationalize the use of chelation therapy and avoid complications related to
iron overload.

To determine the relationship between biochemical indicators and the severity of COVID-19

Dr Saleha Shaheen

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5861-5865

Aim: To determine the relationship between biochemical indicators and the severity of COVID-19.
Methods: Blood samples were obtained by competent doctors and nurses in accordance with ICMR
guidelines. The samples were then forwarded to the central biochemistry laboratory for additional
analysis. The Access-2 completely automated chemical analyzer was used to test ferritin, quantitative
CRP, and IL-6, while the AU 480 analyzer was used to assess LDH.
Results: We included 200 confirmed covid-19 patients in our trial. All of the patients were above the
age of 18. The prevalence of HTN, diabetes, CKD, COPD, and Cardiac Disease in the study patients
was 40%, 32%, and 15%, respectively. 20 and 30 percent, respectively. In the current research, the
mean values of IL-6, ferritin, CRP, and LDH were shown to be higher in covid patients, with the rise
being greater in patients on intubation. The mean and standard deviation of biochemical parameters in
non-ICU, ICU, and intubation patients.
Conclusion: Serum CRP, LDH, IL-6, and ferritin levels that are increased may be employed as
laboratory indicators for a bad prognosis in COVID-19.

Serum Ferritin And Hepcidin Levels In Hepatitis C Patients

Ali Sami Mohammed; Layla Abd-Al-Sattar Sadiq Laylani; Mostafa Ali Abdulrahman; Mohammed Ahmed Mustafa

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 408-411

The aim of the study detects the relation between serum ferritin and hepcidin with hepatitis C virus One hundred subjects (men and women) were taken in the current study. Forty-four subjects without infection used like control group and fifty-six subjects with hepatitis C virus. The results demonstrate high significant (P < 0.05) elevate in levels of serum ferritin and hepcidin in subjects with hepatitis C compare with health subjects. It was concluded that there is positive relationship between serum ferritin, hepcidin and hepatitis C.

Laboratory Markers Versus Ct Severity Score In Predicting Mortality In Covid 19

B.S.Gopala Krishna; P.Pranay Krishna; V.Ravi Sankar; Kondle Raghu; A.Siva Kumar; M. Srikanth; V. Satyanarayana; P. Siri Priya

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 1824-1831

Aim: Predicting the mortality of COVID-19 with a spectrum of complications is a difficult task for prognostication and management. When individual level data of COVID-19 patients were not yet available, there is a need for risk predictors to support the treatment decisions. The study aims to identify the high accurate marker to measure the prognosis and outcome of COVID19.
COVID-19 course is divided into four stages, according to chest computed tomography (C.T.) progress. The demographics, disease exposure history, clinical condition, laboratory tests, computed tomographic chest scan, and outcome data were collected and measured their correlation to assess the risk predictor.
The 10.4% mortality (n=52) was observed in total population. D-dimer (μg/dL) levels observed as 0.75 ± 0.65 in expired patients. NLR ratio observed as 17.1 in expired patients. Ferritin levels were observed as 49.8 ± 32.5 in expired patients. A D-dimer positive predictive value of 72.5% and a negative predictive value of 88% for a predictor of mortality. Ferritin positive predictive value of 35.5% and a negative predictive value of 76.5% for the predictor of mortality. Hence, the AUC of serum ferritin 0.598 represents the poor ability to discriminate the prediction for the cause of death than D-dimer levels. D‐dimer > 2 μg/dL on admission was associated with in‐hospital death. These main findings indicate that D‐dimer on admission >2.0 μg/dl was the independent predictor of hospital death in patients with Covid‐19. A D-dimer has the highest positive predictive value than serum ferritin levels.
Conclusion: The AUC for D- dimer at admission was 0.880, with an optimal cutoff of 2.2 μg/dL in predicting the cause of mortality. D‐dimer on admission > 2.0 μg/mL (fourfold increase) is the best predict in‐hospital mortality and a helpful marker to improve the management of Covid‐19.

Assessment The Levels Of 25(OH) Vitamin D And Ferritin In Patients With Hypothyroid

Amera Kamal Mohammed; Thanaa Abdulmahdi; Zainab Nasser Nabat

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 23-28

Background: Thyroid hormones are essential and have various effects. For instance, they maintain normal growth and regulate metabolism. Hypothyroidism is a condition where the body doesn’t make enough thyroid hormones and people with hypothyroidism usually have a slower metabolism. The serum ferritin levels and vitamin D levels have been changed in patients with Hypothyroidism.
Objective: a study has been carried out to investigate the association among thyroid disorder and the levels of both vitamin D and ferritin.
Materials and Method: The BMI was calculated using the formula BMI= weight (kg)/ height2 (m)2. Vitamin D (25-hydroxyvitamin D), ferritin, T3, T4 and TSH levels were measured using the ELFA (Enzyme Linked Fluorescent Assay, Model: bioMérieux). the results were analysed using SPSS package (version 18).
Results: The results indicated that the age of participants played an ignorable role in this investigation, while significant increases (P<0.05) differences were noticed between the patients and controls in terms of BMI, 25(OH) vit D, ferritin, TSH, T3 and T4. There was also a significant difference(P<0.05) between male and female patients in terms of ferritin, TSH, T3 and T4 in comparison with the controls.
Conclusion: The low levels of Vitamin D and Ferritin concentration were associated with the Patients of hypothyroidism