Background: In India and worldwide lung cancer is the leading cause of cancer mortality. Tobacco smoking is the most important risk factor for Lung Cancer in both genders. Bidi smoking is a more prevalent form of smoked tobacco in India than cigarette smoking. Aim: To study the clinical and pathological profile of lung cancer patients in tertiary care center of western U.P. Method: A total of 172 patients were enrolled from Respiratory Medicine Department, Carrer Institute of Medical Sciences, Lucknow. Hospital based cross sectional study was done. Results: Small cell carcinoma (SCLC) was diagnosed in 23 patients (13.4%), while 129 patients (75%) had Non Small Cell Lung Carcinoma (NSCLC). Within NSCLC, the most common histology was squamous cell carcinoma (SqCC) seen in 65 patients (37.8%) followed by adenocarcinoma (AC) in 48 patients (27.9%), Large cell carcinoma (LCC) in 7 patients (4.1%) and Adenosquamous carcinoma (ASqC) in 4 patients (2.3%).Conclusion: Current study showed Squamous cell carcinoma is still the most common histological type; lung cancer is a male predominant disease owing to smoking habits. Adenocarcinoma is the leading histological subtype among females. Lung cancer is often mistreated as tuberculosis in the Indian subcontinent and hence continues to be diagnosed late.