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Research Article

Urinary biomarkers for the diagnosis of urothelial bladder cancer

Authors:

Jamie J. D'Costa ,

The Medical School, University of Birmingham, Birmingham, UK, GB
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Douglas G. Ward,

The Institute of Cancer & Genomic Sciences, University of Birmingham, Birmingham, UK, GB
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Richard T. Bryanb

The Institute of Cancer & Genomic Sciences, University of Birmingham, Birmingham, UK, GB
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Abstract

Urothelial bladder cancer is a common cancer associated with considerable burden for both patients and healthcare providers alike. The majority of patients present with non-muscle-invasive bladder cancer (NMIBC) which, although not immediately life-threatening, requires appropriate initial management and long-term surveillance which is both invasive and costly. Accurate diagnostic urinary biomarkers could be transformational in this setting, yet have proved to be a significant challenge to bladder cancer scientists over the last two decades. Such biomarkers would need to represent a range of tumour grades and stages, encompass inter- and intra-tumour heterogeneity, and compete with the current diagnostic gold standard of cystoscopy with a sensitivity and specificity of 85% and 87%, respectively. For the field to move forward in this current exciting era of high-throughput proteomics and genomics, bladder cancer scientists need to find a consensus on the optimal urinary substrate (DNA, RNA, protein, etc) and deliver robust well-designed studies in the correct populations with appropriate statistical input. Issues relating to tumour heterogeneity and anticipatory diagnosis also require considerable thought. The challenge remains unchanged.
How to Cite: J. D'Costa, J., G. Ward, D. & T. Bryanb, R., (2016). Urinary biomarkers for the diagnosis of urothelial bladder cancer. New Horizons in Translational Medicine. 3(5), pp.221–223. DOI: http://doi.org/10.1016/j.nhtm.2016.12.001
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Published on 18 Dec 2016.
Peer Reviewed

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