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Reading: Anti-tumor effects of the human monoclonal anti-nuclear antibody on the HEp-2 cells

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Anti-tumor effects of the human monoclonal anti-nuclear antibody on the HEp-2 cells

Authors:

Fengmin Zhang ,

Department of Microbiology, Harbin Medical University; Key Lab for Infection and Immunity of Heilongjiang Province, Key Lab for Pathogenic Biology of Heilongjiang Province Education Bureau, Harbin, China, CN
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Yujun Li,

Department of Microbiology, Harbin Medical University; Key Lab for Infection and Immunity of Heilongjiang Province, Key Lab for Pathogenic Biology of Heilongjiang Province Education Bureau, Harbin, China, CN
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Yong Fang,

Department of Microbiology, Harbin Medical University; Key Lab for Infection and Immunity of Heilongjiang Province, Key Lab for Pathogenic Biology of Heilongjiang Province Education Bureau, Harbin, China, CN
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Wenping Kao,

Department of Microbiology, Harbin Medical University; Key Lab for Infection and Immunity of Heilongjiang Province, Key Lab for Pathogenic Biology of Heilongjiang Province Education Bureau, Harbin, China, CN
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Wuqi Song

Department of Microbiology, Harbin Medical University; Key Lab for Infection and Immunity of Heilongjiang Province, Key Lab for Pathogenic Biology of Heilongjiang Province Education Bureau, Harbin, China, CN
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Abstract

Function of autoantibodies from patients with autoimmune diseases in malignancies development is not clear yet. It has been reported that a cell-penetrating lupus autoantibody, 3E10, which was isolated from a mouse model of systemic lupus erythematosus (SLE), has been a potential targeted therapy for DNA-repair deficient malignancies. We have got four human monoclonal antinuclear antibodies from patients with autoimmune disease, 3B5, 3C1, 3E8 and 4F3. Our data showed that four antibodies could combine HEp-2 cells and display different nuclear types as antinuclear antibody (ANA). Also, these four ANAs can inhibit HEp-2 cells proliferation. We think these antibodies may be potential antibody drugs to cancer therapy. However, the function and mechanism are not clear. Further study, we want to clarify the effects of four ANAs on proliferation of various cancers cells and to investigate the mechanism of four ANAs affecting various cancers cells proliferation and their targets. This may be a new mechanism of malignancies development in patients with autoimmune diseases, and provide novel angle of autoantibody function study.
How to Cite: Zhang, F. et al., (2015). Anti-tumor effects of the human monoclonal anti-nuclear antibody on the HEp-2 cells. New Horizons in Translational Medicine. 2(2), p.65. DOI: http://doi.org/10.1016/j.nhtm.2014.11.035
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Published on 07 Feb 2015.
Peer Reviewed

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