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The Possible Protective Effect Of Saffron Against Acrylamide-Induced Neurotoxicity In Albino Rats (A Molecular Study)

    Authors

    • Ahmed A. Algazeery
    • Samir A. Nassar
    • Abdel-Rahman S. Ballah

    Zoology Department, Faculty of Science, Zagazig University, Zagazig, Egypt

,

Document Type : Research Article

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Abstract

Nowadays, there is a continuous and progressive global public exposure to acrylamide (ACR) due its presence in fried and backed food. Thermal preparation of sugar-rich food mostly initiates chemical reactions that yield dangerous chemicals. Of these chemicals arise acrylamide and its metabolite glycidamide. Those having a high
affinity for binding to nervous tissues. The acrylamide-induced neurotoxicity involves reduction in proliferation of neuronal progenitor cells associated with apoptotic cell death. Concerning acrylamide-induced toxicity, preventive medicine research focused on natural antioxidants. Studies on active constituents of Saffron showed obvious antioxidant, and anti-toxic properties. Here, we designed this study to investigate the possible protective
effect of saffron against acrylamide-induced neurotoxicity in hippocampal area of brain. Adult male albino rats were assigned equally into 4 groups (n = 8); control; saffron group; acrylamide (ACR)-administered group and combined ACR and saffron- treated group. Our results recorded molecular changes as a significant decrease on genomic DNA fragmentation in saffron co-administered group as compared to ACR-exposed group. The changes on DNA mutagenicity were studied by analyzing the random amplification of polymorphism of DNA that showed an elevated genomic integrity on rat co -administered saffron with ACR in contrast to those exposed to ACR only.

Keywords

  • Acrylamide
  • neurotoxicity
  • Brain
  • Saffron
  • DNA
  • RAPD
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European Journal of Molecular & Clinical Medicine
Volume 8, Issue 2
January 2021
Page 2311-2327
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  • PDF Download: 331

APA

Algazeery, A. A., Nassar, S. A., & Ballah, A. S. (2021). The Possible Protective Effect Of Saffron Against Acrylamide-Induced Neurotoxicity In Albino Rats (A Molecular Study). European Journal of Molecular & Clinical Medicine, 8(2), 2311-2327.

MLA

Ahmed A. Algazeery; Samir A. Nassar; Abdel-Rahman S. Ballah. "The Possible Protective Effect Of Saffron Against Acrylamide-Induced Neurotoxicity In Albino Rats (A Molecular Study)". European Journal of Molecular & Clinical Medicine, 8, 2, 2021, 2311-2327.

HARVARD

Algazeery, A. A., Nassar, S. A., Ballah, A. S. (2021). 'The Possible Protective Effect Of Saffron Against Acrylamide-Induced Neurotoxicity In Albino Rats (A Molecular Study)', European Journal of Molecular & Clinical Medicine, 8(2), pp. 2311-2327.

VANCOUVER

Algazeery, A. A., Nassar, S. A., Ballah, A. S. The Possible Protective Effect Of Saffron Against Acrylamide-Induced Neurotoxicity In Albino Rats (A Molecular Study). European Journal of Molecular & Clinical Medicine, 2021; 8(2): 2311-2327.

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