European Journal of Molecular & Clinical Medicine

Abstract

BACKGROUND: Diabetes mellitus (DM) is a group of metabolic diseases, characterized by hyperglycaemia that occurs due to abnormalities in insulin secretion. Uncontrolled diabetes will lead to the development of further complications. HbA1c level measurement is the current gold standard for monitoring glucose levels in DM patients. Glycated albumin (GA) is a fructosamine formed through a non-enzymatic glycation process. There are still few studies on the correlation between HbA1c and GA levels in T2DM patients. Therefore, we decided to investigate the correlation between HbA1c and GA levels in T2DM patients.
OBJECTIVE: To determine the correlation between HbA1c and GA levels in T2DM patients.
METHODS: This study was an observational study with a cross-sectional design conducted on 69 T2DM patients at Diponegoro National Hospital from June to August 2020. We collected data consisting of age, weight, blood pressure, waist circumference, HbA1c and GA levels. We measured HbA1c levels using I-chroma Boditech tool with the enzyme-linked fluorescent assay (ELFA) method, and GA levels using the Architect C8000 tool with an enzymatic method. Finally, we performed statistical analysis using Spearman's correlation test.
RESULTS: The median ± SE values of HbA1c and GA levels were (7.1 ± 0.19%) and (21.2 ± 0.85%), respectively. The Spearman's correlation test results between HbA1c and GA levels were p <0.001; r = 0.775.
DISCUSSION: Maintenance of blood glucose levels in the body is essential for T2DM patients. HbA1c and GA levels can be used for clinical evaluation of T2DM patients.
CONCLUSION: There was a strong significant correlation between HbA1c and GA levels in T2DM patients. HbA1c and GA levels can be used for clinical evaluation of DM patients according to the patient's condition.