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VITAMIN C IN TERMS OF COVID-19, CURRENT TRENDS

    Author

    • IlxamdjanKarimdjanov Asamovich,Nozima Sаdiqova Baxadirovna, BotirTadjiev Mirkhashimovich,NurlanDinmukhammadiev Aktamovich, BobirMirkhashimovBotirovich,YaxyayevaKomola Zokirovna,AnvarTursunbayev Karimberdiyevich,FatimaXoltayeva Fayziyevna
,

Document Type : Research Article

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Abstract

The role of vitamin C in the prevention and treatment of pneumonia andsepsis has been investigated for past decades. This reviewaimsto translatethese findings into patients with severe coronavirus disease (COVID-19). It has indicatedthat patients with pneumonia and sepsis have low vitamin C status and elevated oxidative stress.Additional oral or intravenous (IV) vitamin C administered patients with pneumonia can mitigate the severity and course ofthe disease. Severely ill patients with sepsis need for intravenous administration of amounts counted in grams ofthe vitamin to achieve adequate plasma levels, an intervention that some studies suggest reduces mortality.The vitamin has physiological functions like pleiotropic, many of which are closely connected to COVID-19.These are its antioxidant, antiinflammatory, antithrombotic and immunomodulatory functions.Previous observational studies found out low vitamin C status in critically ill patients with COVID-19.A number of randomized controlled trials (RCTs) conductedworldwideevaluate intravenous vitamin C as monotherapy in patients with COVID-19. Optimization of the intervention protocolsin future trials, e.g., earlier and continuously administration, is justified to potentially improve itsefficacy. In order to the excellent safety profile, low cost, and potential for rapid enlargement of production,administration of vitamin C to patients, especially with hypovitaminosis C and severe respiratory infections,e.g., COVID-19, appears warranted. In addition, there are few new ways of concurrent using vitamin C and other manipulations or medications.

Keywords

  • COVID-19
  • vitamin C
  • Pneumonia
  • sepsis
  • acute respiratorydistress syndrome
  • randomized controlled trials
  • SARS-CoV-2
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European Journal of Molecular & Clinical Medicine
Volume 8, Issue 1
January 2021
Page 1341-1351
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  • Article View: 341
  • PDF Download: 976

APA

Fayziyevna, I. A. S. B. B. M. A. B. Z. K. (2021). VITAMIN C IN TERMS OF COVID-19, CURRENT TRENDS. European Journal of Molecular & Clinical Medicine, 8(1), 1341-1351.

MLA

IlxamdjanKarimdjanov Asamovich,Nozima Sаdiqova Baxadirovna, BotirTadjiev Mirkhashimovich,NurlanDinmukhammadiev Aktamovich, BobirMirkhashimovBotirovich,YaxyayevaKomola Zokirovna,AnvarTursunbayev Karimberdiyevich,FatimaXoltayeva Fayziyevna. "VITAMIN C IN TERMS OF COVID-19, CURRENT TRENDS". European Journal of Molecular & Clinical Medicine, 8, 1, 2021, 1341-1351.

HARVARD

Fayziyevna, I. A. S. B. B. M. A. B. Z. K. (2021). 'VITAMIN C IN TERMS OF COVID-19, CURRENT TRENDS', European Journal of Molecular & Clinical Medicine, 8(1), pp. 1341-1351.

VANCOUVER

Fayziyevna, I. A. S. B. B. M. A. B. Z. K. VITAMIN C IN TERMS OF COVID-19, CURRENT TRENDS. European Journal of Molecular & Clinical Medicine, 2021; 8(1): 1341-1351.

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