Effect of Xanthine Oxidase Inhibition on Immunity Modulation in Human
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 10, Pages 1307-1316
AbstractXanthine oxidase (XO) is a ubiquitous complex cytosolic molybdoflavoprotein which controls the rate limiting step of purine catabolism by converting xanthine to uric acid. It is known that optimum concentrations of uric acid (UA) and reactive oxygen species (ROS) are necessary for normal functioning of the body. Aim: This study is conducted to clarify the impact of xanthinoxidase (XO) inhibition on immunity function in human. Materials & Methods: Patients with renal stone were enrolled in this study. Patients took xanthine oxidase inhibitor (allopurinol) 100 mg/day for 6 months to reduce UA level, and the immune function is estimated by measuring some immunological parameters (IgG, IgA, complement C3 and C4). Blood samples were collected from patients before and after therapy. Autoanalyzer was used to measure the level of uric acid, IgG, IgA, complement C3 and C4. Results: Serum uric acid was significantly lowered after the treatment with allopurinol. Both IgG and IgA were elevated significantly due to allopurinol intake. However, complement C3 and C4 have not been changed after the same period of treatment. Conclusion: Long term inhibition of xanthine oxidase may affect the immunity by modulating immunological parameters in patients with renal stone.
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